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Red Angus News – Exercise intolerance gene mutation identified
By Lindsay Upperman, Ph.D., RAAA director of breed improvement
A new genetic mutation was identified at the University of Nebraska-Lincoln with composite calves, made up of a cross of Red Angus, Simmental and Gelbvieh. The calves in the UNL herd were experiencing exercise intolerance that was exacerbated by stress. For instance, when the herd was being moved to a different pasture, the affected calves tended to not keep up with the herd. They would exhibit muscle fatigue and twitching that would often lead to them laying down or collapsing. After rest, these calves were able to recover and perform normally. In a percentage of cases with extreme or repeated physical exertion the condition can be fatal.
After further research into the genome of these calves, an autosomal recessive genetic defect was identified. This means that both parents of affected calves must carry one copy of the mutation. The affected calves had a change in their genome that caused the PYGM gene to not be developed properly. The PYGM gene produces an enzyme that is used to break down glycogen to ultimately produce energy in muscle cells. The mutation prevented this enzyme from being produced. Furthermore, when taking these affected calves to slaughter, their meat pH was higher than the normal range. A high pH often results in the affected carcass being labeled a dark cutter. Carrier animals showed normal meat pH and meat quality.
Based on the pedigree of the animals utilized at UNL, a common ancestor was found. After testing, the confirmed carrier was BASIN HOBO 79E RAAA #492175. Unfortunately, due to not having available samples on the dam and sire of this carrier, we do not know the status of the parents. The UNL herd also had 4 progeny that were identified as carriers. At this time, no other similar abnormalities have been identified or reported to RAAA within the Red Angus breed.
Sires that have been tested FREE of the mutation include:
RAAA# Name 1260155 BUF CRK THE RIGHT KIND U199 1379610 BROWN PREMIER X7876 1406779 RED SOO LINE POWER EYE 161X 1436844 BIEBER ROLLIN DEEP Y118 1506922 ANDRAS NEW DIRECTION R240 1506931 ANDRAS FUSION R236 1549933 5L DEFENDER 560-30Z 1617230 BIEBER SPARTACUS A193 1619642 3SCC DOMAIN A163 1628086 WFL MERLIN 018A 1683223 H2R PROFITBUILDER B403 1694338 BIEBER DEEP END B597 1701553 5L BLOCKADE 2218-30B 1703720 BROWN ORACLE B112 1725110 PIE CINCH 4126 3491307 RREDS SENECA 731C 3494126 HXC ALLEGIANCE 5502C 3494198 HXC DECLARATION 5504C 3555188 9 MILE FRANCHISE 6305 3751659 BIEBER CL STOCKMARKET E119 3775477 WFL PROFITMAKER E7030 3861137 COLLIER FINISHED PRODUCT 3958815 BIEBER CL ENERGIZE F121 At this time, we are currently developing a stand-alone test for this mutation with Neogen. Once the test is developed, other sire lines will be tested to identify the prevalence of this mutation in the Red Angus Breed.
If you have any questions or would like further details on this mutation, please contact the Dr. Lindsay Upperman, RAAA director of breed improvement at lindsay@redangus.org or 940-387-3502 ext. 29. The paper describing this defect can be found here. Thank you to the staff and students at UNL that worked on this: Mackenzie Batt, Leila Venzor, Rachel Reith, Nicolas Herrera, Dr. Jessica Petersen, Dr. Matt Spangler, Dr. Gary Sullivan, and Dr. David Steffen.
Source : https://redangus.org/exercise-intolerance-gene-mutation-identified/
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ASA Releases Dry Matter Intake EPD in Research Release Format
—Copy of official press release from the American Simmental Association—
Expected progeny differences (EPD) for Dry Matter Intake (DMI) and an economic subindex have been released by the American Simmental Association (ASA) in a research release format. The purpose of these traits is to help breeders better characterize terminal performance by evaluating genetic differences for feed intake and the profitability potential associated with growth relative to intake.
The International Genetic Solutions (IGS) science team is committed to the development of genetic tools that aid breeders in making commercially relevant selection decisions. Being able to identify animals with genetics for more efficient growth relative to feed intake is an industry-wide concern. Feed intake records submitted to IGS partner breed organizations and the existing growth records database were used to develop the DMI EPD and an economic subindex that weighs an animal’s growth potential with respect to its intake to provide a snapshot of that animal’s profitability potential in the feedlot growing phase (growth relative to intake). An extensive validation process was performed over the last year to ensure DMI and subindex were reflective of the existing growth and feed intake records.
At this time there is no official name for the dry matter intake and average daily gain (DMI/ADG) economic subindex, and membership should expect a more formal announcement of the trait near the conclusion of the research release phase.
DMI EPD:
The DMI EPD is expressed as the difference in pounds of daily dry matter intake. A lower EPD is more desirable, as this is representative of the genetic potential for progeny to consume less feed. For example:
Bull A = 1.00 DMI EPD
Bull B = 0.00 DMI EPD
You would expect progeny from Bull B to eat 1 pound less daily dry matter of feed compared to progeny from Bull A.
Feed Intake and Average Daily Gain Economic Subindex (DMI/ADG Subindex):
The economic subindex is expressed as the difference in daily profitability of animals in the feedlot based on their combination of DMI and ADG (Average Daily Gain) EPD. ADG is positively weighted by the value of a pound of gain, and DMI is negatively weighted by the cost of a pound of dry matter. The result of the DMI/ADG Subindex is already factored into both $API and $TI, meaning we already factor the relationship of value of gain to the cost of intake in $API and $TI; however, we are beta testing the merit of publishing a subindex that focuses solely on profit differences due to the genetic levels an animal possesses for gain and intake. For example:
Bull A = $0.10 subindex value
Bull B = $0.00 subindex value
You would expect progeny from Bull A to be $0.10 more profitable per day than progeny from Bull B due to a combination of feed requirements and growth potential.
To view the electronic spreadsheet of DMI and economic subindex on high-use sires and high-accuracy DMI EPD animals in a research format, click here. As research EPD, these will not be evaluated weekly nor published on an animal page on Herdbook.org. It is important to acknowledge that development of both metrics into a weekly genetic evaluation is still under development and may take some time. The IGS science team will periodically update the DMI and economic subindex genetic evaluation as more data is uploaded.
Data Collection
The ASA encourages membership to submit feed intake records on their animals to ASA staff. Reporting feed intake data will greatly help bolster the genetic evaluation, improve prediction accuracy, and help to accelerate the launch of DMI into a weekly genetic evaluation. Members are encouraged to follow these guidelines for feed intake data collection. For more information, members should visit the Beef Improvement Federation guidelines available at guidelines.beefimprovement.org.
Individual feed intake records are often taken post-weaning or around yearling age.
Warm-up period: Depends on the background of the cattle and the type of feed intake system. If calves are already accustomed to eating out of bunks, a seven-day warm-up period with the feed intake system is likely adequate. For cattle that have not yet been bunk-broke, they could need up to a 21-day warm-up period.
Feed Intake Test: Recommend a 42-day minimum, which allows for missed days due to weighing or problems with the intake measurement. Records should be submitted as a measure of dry matter intake. No as-fed data should be reported.
Membership is encouraged to evaluate DMI and DMI/ADG subindex predictions and compare with their expectations. Please remember that DMI is already incorporated in $API and $TI. That said, the new DMI EPD will be more accurate, particularly on animals with genotypes and/or feed intake phenotypes on multiple progeny. Members who have any questions, or those who have submitted feed intake data and would like a full download of EPD on their animals, should contact Lane Giess, ASA Geneticist, at lgiess@simmgene.com.
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RightMate – Precision Matings
RightMate, Precision Mating Technology, Powered by Top Genomics LLC
Genetic providers have had solid tools to assist in making consistent genetic progress for many years. In the past few years improved EPDs, bolstered by the inclusion of genomic evaluation, have been a great step forward to making the potential for progress even greater. Now there is a tested program that offers substantially more rapid improvement and success from your investment in data collection and genomic testing. RightMate generates specific, precision mating options that take full advantage of complementarity genomics between sires and dams plus all of the EPD power created from today’s massive trait databases and it is easy to use. RightMate will absolutely change the trajectory and consistency of your genetic improvement program.
Never before has a tool been available to the beef business that drives positive change and reduce variability so quickly. Yes, RightMate technology can also help you create a more consistent calf crop. With the slow nature of improvement, because of the relatively low reproductive rate of cattle vs. other species, you simply can’t afford to make decisions that don’t assure progress. This is especially true for those with extensive embryo programs. The cost of filling recipient females with embryos from matings that could have been much better, is just too high to take chances.
Genomically assured recommendations are the key! All of us have had experiences when a mating that looked promising and exciting just didn’t work. There are simply some bulls that should be bred to some females on a genomic basis and others that should not, depending on your breeding objectives and desired outcomes. You choose the bulls you wish to use, and RightMate removes those that are marginal or risky choices on a cow-by-cow basis. The final product is a list of the best sire choices for each female ranked according to your breeding objectives along with genetic expectations for each mating result. From that sorted list, you make the call based on your experience and desires for the additional traits that matter to you and your customer’s business.
Managing genetic diversity is another feature of our precision mating tool. For each mating, a “genomic inbreeding” prediction is part of the process and breeding report with appropriate weighting applied to ensure diversity for the future at a level prioritized by the producer. This tool has great potential for commercial herds as well, where minimizing the negative effects of inbreeding can have significant positive effects on profitability.
Since 2019 we have grown to more than 100 customer herds using RightMate and RightChoice technologies with overwhelming success. In 2023 alone we will generate more than 15,000 seedstock mating recommendations and our growing list of commercial customers interested in precision mating is growing quickly as well. The first females created using RightMate precision mating technology are already weaning their second calf crop and using RightMate for the calf sire decisions. The results are just as we had hoped they would be. Herds with much greater rates of genetic improvement for the traits they prioritize, more uniformity and marketability and ultimately more profit for themselves and their customers.
There are currently two RightMate options, but we have customized and blended these options for breeders that wish to. Both options require that raw genotypes are available for Top Genomics to evaluate on every sire and dam in the RightMate or RightMate Plus program.
Better. Stronger. Faster.
RIGHTMATE
Creates genomic mating suggestions for each female in the cow herd and provides decision making tools to guide you through the list of prescribed sires for each female.
Uses the genotypes of up to 20 sires of your choice. You may use different sire lists for heifers vs. cow matings.
RIGHTMATE PLUS
RightMate Plus is designed more for donor or higher impact females.
Females will be test mated to the entire Top Genomic sire database (or by the breed of your choice) and the top choices among the entire list are recommended.
This list of high value sires to choose from with RightMate Plus is large and growing every week.
Want to learn more?
Videos to break RightMate for you or more located here
RightMate Explained – Tom Hook & MartyRopp (5 min)
Quick Overview – Dr. Saatchi (1 min)
Introduction to RightMate – Dr. Saatchi (11 min)


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Hydrops Update from ASA

From the Desk of Wade Shafer, EVP March 8,2024 Hello,
As many of you are aware, the American Simmental Association has been investigating a developing genetic condition that causes Hydrops pregnancies in a certain line of Simmental genetics. Reports involve daughters and granddaughters of the bull WS All Aboard B80, ASA# 2852207, and pregnancies created by embryo transfers of daughters. The complications of pregnancy with the condition usually result in loss of the calf and occasional loss of the dam. Early pregnancy termination will save the cow. Late-stage induction and attended birth may save the cow and calf. You should consult with your herd veterinarian for final determination of how to manage the pregnancy.
We are sending this letter directly to members with descendants of WS All Aboard B80 reported in their operation, sales managers interfacing with members potentially selling related genetics, state associations, and SimSpecialists.
Here are some updates in relation to this research and ASA’s actions/suggestions.
Ongoing Research The ASA staff and University of Nebraska–Lincoln research team are working diligently to thoroughly document the pathology related to this condition to find a causative mutation that can be used for a DNA test. A large genotyping investigation has zeroed in on a region of the chromosome that is likely to contain the causative mutation. Continued investigation, sequencing, genotyping, and analysis is ongoing.
Late in 2023 another project was initiated that will track these pregnancies from conception through to the end of pregnancy to monitor fetal development, potential abnormalities with the pregnancy throughout gestation, and thoroughly document the Hydrops condition and sample collection. This research is ongoing with the pregnancies nearing three months along.
In addition to the above research, the ASA and UNL are collecting information and samples on active Hydrops cases. It is our sincere hope that we will find a DNA test as soon as possible in order to deliver more certainty and informed decisions to the operations with WS All Aboard genetics. TraitTrac Hydrops has been added to Herdbook’s TraitTrac with WS All Aboard B80 listed as a documented carrier. At this time there are no genetic holds placed on his descendants as there is not a DNA test available yet. Once there is a test, then Hydrops will follow the same policy as other genetic conditions.
ASA Recommended Marketing Statement for WS All Aboard B80 descendants Female progeny who are descendants of or are directly sired by WS All Aboard B80 (ASA# 2852207) are at risk for carrying a genetic abnormality called Hydrops. Daughters may develop a serious condition during late gestation that results in excess fluid in the fetal membrane which typically causes the loss of the calf and occasionally the dam. There is no current test at this time to identify animals carrying this mutation. Research is ongoing regarding the transmission of the abnormality, and to develop a genetic test. Helping our producers navigate this issue is of the utmost importance to us. Therefore, given that there is neither a full understanding of this condition nor a test, careful consideration should be given regarding the question of whether to breed WS All Aboard B80 descendant females until more information is available to breeders.
For questions regarding established WS All Aboard B80 genetics, Hydrops symptoms, reporting an active case, or additional information, please visit the Hydrops Information Center at www.simmental.org or reach out to Jackie Atkins at jatkins@simmgene.com.To read more about Hydrops click here -
DNA Sample Collection

The American Angus Association and Angus Genetics Inc. (AGI) have a great informational page about the different DNA sample collection types and best practices for each. If you have any questions about which sample type may be best for your operation, reach out so we can discuss. Keep in mind, you can apply this logic across any breed association business you work with, it’s not exclusive to black Angus cattle.
https://www.angus.org/agi/submittingsamples

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Suggested Sale Terms & Conditions by Breed Associations

Most Associations publish guidelines for the marketing & sale of registered animals. Here are the links for each breed so you can ensure you’re in alignment with what is encouraged for sellers to abide by for registered stock.
Red Angus Association of America
American Simmental Association
North American Limousin Foundation
American Black Hereford Association
American International Charolais Association
American Shorthorn Association
American Maine-Anjou Association
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Milk EPD – Does it Work?

Dr. Wade Shafer, Ph.D wrote this article back in 2011 and when we discussed the Milk EPD again last summer, he forwarded this to me and stated the logic still applies today. If you have questions on the Milk EPD, this does a great job breaking it down for us.
An Examination of Milk EPDs
A discussion of the validity of EPDs for milk.
By Wade Shafer, Ph.D., ASA Director of Performance Programs
Published in March 2011
Over the last several years I have fielded too many calls to count from breeders feeling that Milk EPDs do not do justice in gauging their herd’s genetic milking ability. Though you may not be one of the many breeders who have voiced reservations about Milk EPDs to me directly, I suspect
you may have had qualms with them from time to time. In talking with people of other breeds, this sentiment is not unique to Simmental breeders. Though many breeders may question the validity of milk EPDs, they are without a doubt the best predictor we have
of animals’ genetic level for milk. That said, when we scrutinize the situation, breeders’ skepticism about Milk EPDs is understandable. In the following paragraphs I will explain why EPDs gauge genetic level for
milk as accurately as possible and offer up my opinions as to why breeders often question their validity. To understand a widely held belief, it usually helps to get at the root of it. What is at the core of breeders’ misgivings about Milk EPDs? From my experience, breeders seldom question milk EPDs on sires — rather, doubt tends to permeate when cows in their herd wean big calves yet have lower-percentile
Milk EPDs. On the surface, their skepticism seems justified. It just seems logical that high-producing cows should have upper-end milk EPDs. It turns out there are solid reasons why a top producing cow does not
necessarily possess genes for high levels of milk production — and, therefore, should not have high-level milk EPDs. To gain some perspective, let’s take a look at factors affecting the measurement
we use to gauge milking ability — weaning weights. (Obviously, we do not have the latitude to measure milk directly, as does the dairy industry. Even if we could, the trait we are concerned with in the beef business is the pounds of weaned calf expected from a cow due to the genes she
possesses for milk and mothering ability — which we can compute using weaning weights.) From a cow’s genetic perspective, the weaning weight of her calf is affected by her own milk genes and half of her weaning weight genes (the calf carries half of her genes). (This fact is the reason
Maternal Weaning Weight EPD is calculated as Milk EPD+ ½ Weaning Weight EPD.) Beyond that, there are non-genetic factors affecting the calf’s weaning weight (age of its dam, stocking rate, weather, creep feed, and many other non genetic effects we are not able to distinguish).
Due to the myriad of factors affecting weaning weight, using actual and/or adjusted weaning weights and/or ratios will not serve us well in predicting an animal’s genetic value for milk production. One glaring shortcoming of these statistics is that they do not partition weaning weight into separate growth and milk components — an obvious requisite for assessing milk genetics. Besides that monumental failing, weights and ratios do little to nothing when it comes to sifting through the non-genetic influences on weaning weight and they ignore information on relatives. Because the methodology used to calculate EPDs (Best Linear Unbiased Prediction; BLUP) allows us to parse weaning weight by the factors that impact it, EPDs permit us to zero in on an animal’s genetics for milk — independent of all the other factors. This is accomplished by leveraging the sophisticated statistical techniques of BLUP on the 6 million+ weaning weights in our database. These features make EPDs vastly superior to other methods of gauging milk genetics.
After extolling the virtues of EPDs, how is it that we can have cows that wean heavy calves with poor milk EPDs (and vice versa)? One obvious reason is that these cows may be weaning heavy calves via exceptional
growth genes they pass to their calves. (Just look through ASA’s database and you will find plenty of animals that have low Milk EPDs but high Maternal Weaning Weight EPDs due to their extreme growth. Remember, Maternal Weaning Weight EPD = Milk EPD+ ½ Weaning Weight.) A typical retort to this assertion is “how could the calf express exceptional growth if the cow did not give loads of milk?” Though high levels of milk certainly help a calf express its growth potential, a calf gets a significant amount of its nutrients from sources other than milk
(particularly after the first few months). Another plausible cause for a heavy weaning calf out of a low milk EPD cow is simply that she produced lots of milk. In these circumstances, our genetic evaluation is telling us that the reason for the souped-up milk production is likely non-
genetic in nature. This is a big pill to swallow, as we tend to assume
that a heavy milking cow must be genetically outstanding for milk
production; however, since milk production is only low to moderately
heritable we should not be surprised to have heavy milking cows that
are below average genetically, and vice versa. From a genetic evaluation standpoint, milk’s meager heritability means that it takes more data to move Milk EPDs and improve accuracies than it does with more heritable traits (e.g., growth and carcass). Since a cow is quite limited in the number of calves she can have naturally, unless she has numerous daughters (typically only possible for donor cows) and they have many calves or her sire or maternal grandsire change dramatically for milk, a colossal shift in her milk EPD from where she starts is not in the cards. A big jump in accuracy is just as unlikely. These limitations do not in any way imply fault with EPDs, the limitations are simply a function of biology — low heritability and small numbers of offspring are not conducive to accurate estimation. Always keep in mind, however, even though a cow’s Milk EPDs may not be highly accurate, research has clearly shown that they are far and away the most accurate estimate of her genetic merit for milk. In our population we have estimated the heritability of milk to be 16%. This means 84% (100% – 16%) of the differences in milk production between cows during a lactation are due to non-genetic factors — and that is after we remove differences due to age and contemporary group (i.e., herd, pasture). Given these circumstances, it iseasy to see that a cow’s milk production ability may be very different than the genes she possesses for the trait.



